Practice MCQ For Govt Pharmacist Exam, in this article we will solve, Practice MCQ impurities, its source, types and tests of purity. Read following article for your reference.
Impurities: It’s Sources, Types And Test Of Purity. » PHARMACAREERS
The primary purpose of the Pharmacopoeia is to:
A) Provide guidelines for clinical trials
B) Set standards for pharmaceutical substances
C) Regulate pharmaceutical marketing
D) Conduct research on new drugs
Which of the following is NOT a type of impurity commonly found in pharmaceutical substances?
A) Organic impurities
B) Inorganic impurities
C) Enantiomeric impurities
D) Microbial impurities
The limit test for Chloride in pharmaceutical substances is based on the principle of:
A) Precipitation
B) Complexation
C) Oxidation-reduction
D) Absorption spectroscopy
Which heavy metal is specifically tested using the limit test for Arsenic?
A) Lead
B) Mercury
C) Cadmium
D) Arsenic
The modified limit test for Sulphates is designed to:
A) Detect lower concentrations of Sulphates
B) Test for Sulphates in volatile substances
C) Differentiate between Sulphates and other anions
D) Increase the speed of the analysis
Sources of impurities in pharmaceuticals can include:
A) Manufacturing process
B) Degradation products
C) Contamination during packaging
D) All of the above
The limit test for Iron in pharmaceutical substances utilizes which reagent?
A) Potassium permanganate
B) Thioglycolic acid
C) Potassium thiocyanate
D) Nessler’s reagent
Impurities that arise from the synthesis or preparation of a drug substance are called:
A) Process impurities
B) Environmental impurities
C) Degradation impurities
D) Excipient impurities
The principle involved in the limit test for Lead is:
A) Precipitation as lead sulphide
B) Formation of a colored complex
C) Volatilization as lead chloride
D) Electrochemical detection
Which Pharmacopoeia was the first to be published?
A) United States Pharmacopoeia (USP)
B) British Pharmacopoeia (BP)
C) European Pharmacopoeia (EP)
D) Indian Pharmacopoeia (IP)
The limit test for Heavy metals generally involves:
A) Flame photometry
B) Atomic absorption spectroscopy
C) Colorimetric analysis
D) Gravimetric analysis
Organic impurities in pharmaceuticals are typically characterized by:
A) Melting point determination
B) Thin-layer chromatography (TLC)
C) Gas chromatography (GC)
D) Both B and C
The presence of which impurity is specifically checked by the limit test for Arsenic?
A) Arsenic trioxide
B) Arsenic pentoxide
C) Arsenous acid
D) Arsenic sulfide
Inorganic impurities in pharmaceutical substances can be introduced through:
A) Raw materials
B) Catalysts used in synthesis
C) Water used in manufacturing
D) All of the above
The limit test for Sulphate is based on the formation of:
A) Barium sulphate precipitate
B) Sulphur dioxide gas
C) Colored sulphate complex
D) Sulphuric acid
Which of the following is NOT a principle involved in a limit test?
A) Precipitation reaction
B) Redox reaction
C) Acid-base neutralization
D) Complex formation
The modified limit test for Chlorides is used when:
A) The sample is colored or turbid
B) The sample is oily or viscous
C) The concentration of Chlorides is very high
D) The sample is a volatile substance
Enantiomeric impurities are best separated and identified by:
A) High-performance liquid chromatography (HPLC)
B) Capillary electrophoresis (CE)
C) Chiral chromatography
D) Mass spectrometry (MS)
Which reagent is used in the limit test for Iron to form a red-colored complex?
A) Potassium ferrocyanide
B) Potassium ferricyanide
C) Potassium dichromate
D) Potassium iodide
The principle of the limit test for Heavy metals is based on:
A) Precipitation as sulphides
B) Formation of colored complexes
C) Volatilization as chlorides
D) Oxidation-reduction reactions
A Pharmacopoeia is legally binding in:
A) The country it is published
B) Internationally
C) The region it covers
D) None of the above
The limit test for Arsenic involves the generation of:
A) Arsenic trichloride
B) Arsenic hydride
C) Arsenic pentoxide
D) Arsenous sulphide
Which of the following impurities is likely to be found in a drug substance due to degradation over time?
A) Process-related impurities
B) Heavy metals
C) Degradation products
D) Enantiomeric impurities
The limit test for Chlorides can be modified by using:
A) Silver nitrate with nitric acid
B) Silver nitrate with ammonia
C) Silver nitrate with acetic acid
D) Silver nitrate with hydrochloric acid
The presence of which element is detected in the limit test for Sulphate?
A) Sodium
B) Barium
C) Calcium
D) Magnesium
Which technique is NOT commonly used for detecting organic impurities?
A) Nuclear magnetic resonance (NMR)
B) Infrared spectroscopy (IR)
C) Ultraviolet-visible spectroscopy (UV-Vis)
D) Polarimetry
The limit test for Iron is sensitive to what concentration range?
A) 1-10 ppm
B) 10-100 ppm
C) 0.1-1 ppm
D) 0.01-0.1 ppm
Which of the following is NOT a source of heavy metal impurities?
A) Water used in manufacturing processes
B) Equipment used in manufacturing processes
C) Packaging materials
D) Biological synthesis
The limit test for Lead is based on the principle of:
A) Precipitation as lead chloride
B) Formation of a colored complex with dithizone
C) Volatilization as lead acetate
D) Electrochemical detection
Modified limit tests are used when:
A) Standard tests are not sensitive enough
B) The sample has interfering substances
C) There’s a need for rapid testing
D) All of the above
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