Practice MCQ For Government Pharmacist Exams

Practice MCQ For Government Pharmacist Exams

Pharmaceutics I Unit IV

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Suppositories: Definition, types, advantages and disadvantages, types of bases, methods of preparations. Displacement value & its calculations, evaluation of suppositories.

Pharmaceutical incompatibilities:  Definition, classification, physical, chemical and therapeutic incompatibilities with examples.

Definition of suppository: 

a) A solid dosage form for oral administration.

b) A solid dosage form for topical application.

c) A solid dosage form inserted into a body cavity for local or systemic action.

d) A liquid dosage form for injection.


Types of suppositories:

a) Rectal only.

b) Rectal and vaginal.

c) Rectal, vaginal, and urethral.

d) All of the above.

Advantages of suppositories:

a) Bypasses first-pass metabolism.

b) Convenient for patients with swallowing difficulties.

c) Provides localized action.

d) All of the above.


Disadvantages of suppositories:

a) Can be irritating to the rectum.

b) Unpleasant sensation of fullness.

c) Slow onset of action compared to some routes.

d) All of the above.


Types of suppository bases:

a) Water-soluble only (e.g., polyethylene glycol).

b) Fat-soluble only (e.g., theobroma oil).

c) Water-soluble and fat-soluble.

d) None of the above.


Methods of suppository preparation:

a) Molding.

b) Compression.

c) Both molding and compression.

d) Neither molding nor compression.


Displacement value:

a) The volume occupied by 1 gram of the suppository base.

b) The weight of the suppository base required to displace a specific volume of water.

c) The amount of drug that can be incorporated into a suppository.

d) A measure of the suppository’s melting point.


Calculating displacement value:

a) Displacement Value = Weight of base / Volume of displaced water

b) Displacement Value = Volume of displaced water / Weight of base

c) Displacement Value = Drug amount / Base amount

d) Displacement Value = Melting point / Displacement value


Evaluation of suppositories:

a) Weight variation.

b) Uniformity of content.

c) Melting point/dissolution rate.

d) All of the above.


Which of the following suppository bases is water-soluble?

a) Theobroma oil

b) Cocoa butter (another name for theobroma oil)

c) Polyethylene glycol

d) Stearyl alcohol


Suppositories are most commonly used to deliver medications for:

a) Chronic conditions

b) Localized conditions

c) Antibacterial purposes

d) Pain relief


Which of the following statements about suppository storage is CORRECT?

a) They should be stored at room temperature.

b) They should be refrigerated.

c) Storage temperature depends on the base type.

d) They should be stored in a tightly sealed container regardless of temperature.


Patients with nausea and vomiting may have difficulty using suppositories because of:

a) The suppository may irritate the rectum.

b) The medication may not be absorbed properly.

c) It may trigger the gag reflex.

d) All of the above.


Suppositories for children are typically:

a) Larger than adult suppositories.

b) Smaller than adult suppositories.

c) The same size as adult suppositories.

d) Not recommended for use in children.


When inserting a suppository, it’s important to:

a) Wash hands thoroughly before and after insertion.

b) Moisten the suppository with water.

c) Insert it as deeply as possible.

d) Lie down for 30 minutes after insertion.


If a suppository expels shortly after insertion, it could be a sign of:

a) Incorrect storage.

b) An improper dose.

c) The medication is not effective.

d) Constipation.


Which of the following medications is NOT typically administered via suppository?

a) Anti-nausea medication (for some cases)

b) Pain medication (for localized pain)

c) Antidepressants

d) Anti-diarrheal medication


For suppositories to be effective, they need to:

a) Dissolve quickly at body temperature.

b) Remain solid for an extended period.

c) Be uncomfortable to insert.

d) Have a strong odor.


Suppositories can be a good alternative for patients who have difficulty with:

a) Swallowing pills.

b) Injections.

c) Taking medication orally.

d) All of the above.


It’s important to consult with a healthcare professional before using suppositories, especially if:

a) You are pregnant or breastfeeding.

b) You have any underlying rectal conditions.

c) You are taking other medications.

d) All of the above.


Definition:** Pharmaceutical incompatibility refers to:

a) The inability of a medication to work effectively.

b) Interactions between drug and food that affect absorption.

c) Undesirable interactions between different drug components or with excipients.

d) The breakdown of a drug due to improper storage.


Classification of incompatibilities:

a) Physical and chemical only.

b) Physical, chemical, and therapeutic.

c) Dosage form and route of administration.

d) Age and gender of the patient.


Example of a physical incompatibility:

a) Antagonistic effect between two medications.

b) Formation of a precipitate when mixing solutions.

c) Increased blood sugar levels due to a drug-food interaction.

d) Medication causing drowsiness in an elderly patient.


Example of a chemical incompatibility:

a) Combining an acidic and basic medication, leading to neutralization.

b) A medication not being absorbed properly due to food intake.

c) Two medications with similar actions causing an additive effect.

d) A medication causing nausea in a child.


Therapeutic incompatibility:

a) Occurs when medications have opposing therapeutic effects.

b) Results in changes in the physical appearance of a medication.

c) Affects the absorption rate of a drug due to food interaction.

d) Leads to the breakdown of a medication due to improper storage.


Example of a therapeutic incompatibility:

a) Mixing an antibiotic with a laxative.

b) Combining two medications for pain relief, leading to an increased effect.

c) A medication causing a bad taste in the mouth.

d) A suppository melting too quickly at room temperature.


Identifying and preventing incompatibilities is important for:

a) Ensuring medication effectiveness and patient safety.

b) Reducing the cost of medications.

c) Improving the taste of medications.

d) Extending the shelf life of medications.


Pharmacists play a crucial role in:

a) Identifying potential incompatibilities in prescriptions.

b) Recommending alternative medications if necessary.

c) Educating patients on proper medication storage and use.

d) All of the above.


When encountering an incompatibility, a pharmacist may:

a) Dispense the medication as prescribed.

b) Inform the prescriber and suggest alternative options.

c) Adjust the dosage of one of the medications.

d) Recommend a different route of administration for one medication.


Resources for pharmacists to check for incompatibilities include:

a) Drug compendia and references.

b) Manufacturer information for specific medications.

c) Both a and b.

d) Patient medication history.


Continuous education for pharmacists is essential to stay updated on:

a) New medications and potential interactions.

b) Changes in recommended prescribing practices.

c) Advancements in pharmaceutical technology.

d) All of the above.


Which of the following statements about physical incompatibilities is true?

a) They always result in a loss of medication potency.

b) They can be visually identified by changes in appearance.

c) They are not a major concern for pharmacists.

d) They can be overcome by adjusting the dosage form.


Chemical incompatibilities can lead to:

a) Formation of precipitates or gas.

b) Changes in color, odor, or taste.

c) Loss of medication effectiveness.

d) All of the above.


Combining a diuretic with lithium can be an example of:

a) Physical incompatibility.

b) Chemical incompatibility.

c) Therapeutic incompatibility.

d) Dosage form incompatibility.


It’s important to consider therapeutic incompatibilities when prescribing medications for:

a) The same condition.

b) Different conditions that can interact.

c) Both a and b.

d) None of the above.


When dispensing medications, a pharmacist should provide instructions on:

a) Potential interactions with food or other medications.

b) Proper storage and handling of medications.

c) How and when to take the medications.

d) All of the above.


Patients should be encouraged to:

a) Inform their pharmacist about all medications they are taking.

b) Report any unusual side effects they experience.

c) Not take expired medications.

d) All of the above.


By working together, pharmacists and healthcare professionals can:

a) Minimize the risk of medication errors.

b) Ensure optimal patient care and medication safety.

c) Improve patient adherence to medication regimens.

d) All of the above.


By working together, pharmacists and healthcare professionals can:

a) Minimize the risk of medication errors.

b) Ensure optimal patient care and medication safety.

c) Improve patient adherence to medication regimens.

d) All of the above.


Incompatibilities can affect the:

a) Stability of a medication.

b) Absorption rate of a drug.

c) Release profile of a medication.

d) All of the above.

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