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Local Anaesthetic Agents
Local Anaesthetic Agents Local anaesthetic agents play a crucial role in modern medicine by providing targeted pain relief during various medical and dental procedures. Understanding their mechanisms, classifications, and clinical applications is essential for pharmacy graduates and healthcare professionals. In this article, we will explore the fascinating world of local anaesthetics, their historical development, and
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Drug Discovery and Clinical Evaluation of New Drugs
Drug Discovery and Clinical Evaluation of New Drugs The journey from a scientific concept to a marketable drug is a complex and rigorous process that spans several critical phases. Drug discovery and clinical evaluation are essential components of this journey, ensuring that new drugs are both effective and safe for human use. With the increasing
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Receptor Theories and Classification of Receptors, Regulation of Receptors
Receptor Theories and Classification of Receptors, Regulation of Receptors Receptors are fundamental components in the field of pharmacology, playing a crucial role in mediating the effects of drugs and endogenous substances on the body. Understanding how receptors function, their classification, and the principles that govern their behaviour is essential for developing new therapeutic agents and
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Enzyme Induction, Enzyme Inhibition, Kinetics of Elimination
Enzyme Induction, Enzyme Inhibition, Kinetics of Elimination Pharmacology, the science of drugs and their effects on living systems, is a cornerstone of medical and pharmaceutical education. Among the many facets of pharmacology, understanding how drugs are metabolized in the body is crucial for predicting their efficacy and safety. This article delves into three key concepts
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Pharmacodynamics- Principles and Mechanism of Drug Action
Pharmacodynamics- Principles and Mechanism of Drug Action Pharmacodynamics, a core area of pharmacology, delves into the intricate interactions between drugs and the biological systems they affect. Unlike pharmacokinetics, which focuses on the absorption, distribution, metabolism, and excretion of drugs, pharmacodynamics explores the effects of drugs on the body and how these effects are achieved. This
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Distribution of Drugs
Distribution of drugs Distribution in pharmacokinetics refers to the reversible movement of a medication from one part of the body to another. A medication needs to be dispersed into intracellular and interstitial fluids after it is directly administered or absorbed and goes into systemic circulation. Once a medication enters the bloodstream, it is dispersed to
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Absorption of Drugs
Absorption of drugs Absorption is defined as the movement of drugs or medications from its site of administration into the bloodstream. The rate of absorption is just as significant as the portion of the administered dose that is absorbed. The medication must pass through biological membranes, unless it is administered intravenously. Absorption is governed by
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Pharmacokinetics : Membrane Transport of Drugs
Pharmacokinetics Pharmacokinetics is defined as the quantitative study of a drug’s entry, passage through, and exit from the body. The pharmacokinetic properties of the drug determine its concentration at the site of action, which in turn affects the intensity of response. The route of administration, dosage, latency of onset, time of peak action, duration of
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